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Volume 36 , Issue 2
March/April 2016
Pages e16–e25

Socket Preservation Therapy with Acellular Dermal Matrix and Mineralized Bone Allograft After Tooth Extraction in Humans: A Clinical and Histomorphometric Study

Patricia Garani Fernandes, DDM, MSc/Valdir Antonio Muglia, DDS, MSc, PhD/Danilo Maeda Reino, DDM, MSc/Luciana Prado Maia, DDM, MSc/Marcio Fernando de Moraes Grisi, DDS, MSc, PhD/Sergio Luís Scombatti de Souza, DDS, MSc, PhD/Mario Taba, Jr, DDS, MSc, PhD/Daniela Bazan Palioto, DDS, MSc, PhD/Adriana G. de Almeida/Arthur Belém Novaes, Jr, DDS, MSc, PhD

PMID: 26901306
DOI: 10.11607/prd.2307

The aim of this study was to analyze through clinical and histomorphometric parameters the use of acellular dermal matrix (ADM) with or without mineralized bone allograft (AB) on bone formation in human alveoli after a 6- to 8-month healing period. A total of 19 patients in need of extraction of the maxillary anterior teeth were selected and randomly assigned to the test group (ADM plus AB) or to the control group (ADM only). Clinical and histomorphometric measurements and histologic analysis were recorded 6 to 8 months after ridge preservation procedures. Clinical parameters and amount of mineralized and nonmineralized tissue were measured and analyzed. In the clinical measurements, the test group showed reduced bone loss in the buccopalatal dimension after 6 to 8 months (intragroup analysis P < .01). Histologic findings showed higher percentages of mineralized tissue and lower percentages of nonmineralized tissue in the test group when compared with the control group (P < .05). In this randomized controlled clinical and histomorphometric study in humans, acellular dermal matrix in association with mineralized bone allograft reduced alveolar bone loss in the anterior maxillae both in height and width after a follow-up period of 6 to 8 months.

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